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Related topics: Protein Expression, Sample Preparation

11/2017

Reducing sample preparation time from Sf9 insect cultures by using Sartoclear Dynamics® Lab

Sartoclear Dynamics® Lab V500 Kit was tested as a novel method for the clarification of a recombinant protein expressed in Sf9 cells without a centrifuge. It is shown that Sartoclear Dynamics® Lab offers significant time savings over conventional methods with no noticeable effect on protein yield.

Author: John Cashman

View Application Note

Related topics: Oncology, Antibody Discovery, Filtration, Sample Preparation

11/2017

Impact of the Claristep® Filtration System on Recovery and Adsorption of Various Therapeutic Proteins at Low Sample Volumes

We have tested the novel filter device Claristep® for the preparation of protein samples containing four different therapeutic proteins by using RP and SEC HPLC. We observed no significantly reduction of the product concentration at 1 mg/mL and an insignificant binding of ~4.0 µg mAb per filter.

Author: Alexander Croon, Johannes Felix Buyel

View Application Note

Products:
Claristep

Related topics: Liquid Handling/Pipetting

11/2017

How to Select a Mechanical Pipette

Points to consider when choosing a Mechanical Pipette

View Practical Selection Guide

Related topics: Liquid Handling/Pipetting

Related topics: Antibody Discovery, Protein Expression, Protein Concentration & Purification

9/2017

Vivaflow® 200: A critical sample preparation tool for concentrating hybridoma supernatants

This study focusses on the use of Vivaflow® 200 crossflow cassettes to concentrate up to 3 L clear murine hybridoma supernatant 10-fold prior to affinity chromatography. Consistent antibody recoveries in excess of 98 % at speeds of concentration around 20 – 25 mL/min are observed.

Author: Mike Brownleader, Ian Phillips, Andy Wright

View Application Note

Products:
Vivaflow® 200

Related topics: Sample Preparation

9/2017

Claristep® Filtration Assembly – A Novel Sample Preparation Method suitable for the Analytics of Phthalates in Solid Environmental Samples

We demonstrate that Claristep® syringeless filter units 0.45 and 0.2 μm are suitable for the clean-up of phthalate samples prior to GC-MS. A mix of eighth phthalates was filtered at a concentration of 10 μg/mL with neither detectable adsorption nor releasing of these compounds from the filter unit.

Author: Roberto Menzel, Kristin Menzel, Klaus Schöne

View Application Note

Products:
Claristep

Related topics: Sample Preparation

9/2017

Analyzing Drinking Water by ICP-MS for Heavy Metal Detection

We show that the Minisart® syringe filter units have a very high degree of purity and the metal ions extracted from them are below the detection limit or considerably lower than the limits established by regulatory requirements. ICP-MS technology was selected as the method for analysis.

Author: Klaus Schöne

View Article

Related topics: Sample Preparation

6/2017

Sartorius Ultrafiltration Products in the Preparation of Biological and Medical Nanocarriers – a Short Review

This short review provides examples of recent literature dealing with the preparation of Nanoparticles. Particular focus is laid on the concentration and purification steps which were performed via ultrafiltration with Sartorius Vivaspin® or Vivaflow® devices with different pore sizes (MWCO).

Author: Dr. Hannes Landmann, Dr. Kristin Menzel

View Application Guide

Products:
Ultrafiltration

Related topics: Oncology, Immuno-Oncology, Oncology General

2/2017

Juno´s Cell Handling Platform for Efficient Production of Gene-Modified T-Cells - Lecture Research Xchange Forum 2017

"The integration of single-use technology in fill and finish guarantees a high effective running machine while reducing the risk of cross-contamination and ensuring higher handling and production safety."

Author: Dr. Lothar Germeroth

View Lecture Video

Related topics: Oncology, Immuno-Oncology, Oncology General

2/2017

ImmTAC™ Molecules: Novel Bi-functional TCR-based Biologicals For Targeted Immunotherapy - Lecture Research Xchange Forum 2017

The development of a unique biologic platform to produce Immune mobilising monoclonal TCRs Against Cancer (ImmTAC) joins a growing armamentarium of immunotherapies that offer exciting approaches to deliver durable antibody responses in oncology.

Author: Nicola M.G. Smith, PhD

View Lecture Video

Related topics: Oncology, Oncology General

2/2017

PRL-3 phosphatase: Roles and targeting in cancer - Lecture Research Xchange Forum 2017

"Tumor-promoting PRL-3 is suggested as a therapeutic target in cancer cells. Thus, finding inhibitors would be highly desirable. Presented here are findings from studying PRL-3 in epithelial 3D cell culture models and the challenging endeavors of inhibitor development for PRL-3."

Author: Prof. Dr. Maja Köhn

View Lecture Video

Related topics: Oncology, Oncology General

2/2017

Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma - Lecture Research Xchange Forum 2017

The findings from this trial highlight the multiplicity of mutation-based pathologies and pinpoint novel precision-based therapeutic strategies to pursue for intrahepatic cholangiocarcinoma, and potentially, in future basket trials of diverse tumors using a similar stratification approach.

Author: Assoc. Prof. Dr. Jesper Bøje Andersen

View Lecture Video

Related topics: Oncology, Oncology General

2/2017

The p53-Mdm2 system modifies chromatin and DNA replication - Lecture Research Xchange Forum 2017

New discoveries in p53 research elucidate that the p53-Mdm2 system provides means to maintain DNA integrity and chromatin stability. These novel activities provide potential targets and opportunities for selectively interfering with tumor cell proliferation.

Author: Prof. Dr. med. Matthias Dobbelstein

View Lecture Video

Related topics: Oncology, Immuno-Oncology, Oncology General

2/2017

Expansion of T cells for autologous T cell therapies: Assessment of novel stirred tank bioreactor - Lecture Research Xchange Forum 2017

Facing the challenges in the development of suspension-based autologous cell therapies and manufacturing of personalized medicinal products using cell culture under GMP-conditions this study presents ways to overcome obstacles by employing the ambr 250 modular expansion system from Sartorius.

Author: Dr. Henrieta Fraser

View Lecture Video

Related topics: Oncology, Oncology General

2/2017

Translational potential of non-coding RNAs in oncology - Lecture Research Xchange Forum 2017

"Based on recent observations, state-of-the-art knowledge of ncRNAs’ functioning in cancer biology as well as their translational potential to serve as disease biomarkers in diagnostics and as novel therapeutic targets in cancer therapy are summarized and demonstrated by providing several examples."

Author: Assoc. Prof. Dr. Ondřej Slabý

View Lecture Video

Related topics: Oncology, Oncology General

2/2017

Ultra scale-down approach to process design - Lecture Research Xchange Forum 2017

The research presented here focuses on USD studies of the bioprocessing of antibody products, the use of flocculation as a solution to processing challenges and the combined study of centrifugation and depth filtration as options in the primary recovery of a mammalian expression system.

Author: Dr. Alex Chatel

View Lecture Video

Related topics: Oncology, Immuno-Oncology, Oncology General

2/2017

Antibody Drug Conjugates – State of the Art, Trends, Challenges and Opportunities Lecture Research Xchange Forum 2017

Antibody drug conjugates (ADCs) seek to combine the cytotoxic potential of a pharmacologically active small-molecule drug with the specificity of mAbs. During this session, different types of ADC constructs, promising conjugation technologies, and also the challenges of ADCs are introduced.

Author: Zaki Sellam

View Lecture Video

Related topics: Oncology, Oncology General

2/2017

Panel Discussion: How to improve knowledge transfer on oncology between academia & industry - Research Xchange Forum 2017

Watch the controversial discussion at the Sartorius Research Xchange Forum 2017 in Goettingen with 3 external experts about how to improve knowledge transfer on oncology between the interplay of academia, society and industry.

View Event Talk

Related topics: Oncology, Oncology General

2/2017

Research Xchange Forum 2017 - Trends and Challenges in Oncology

It was all about exchanging when internationally renowned academics and leading biopharma R&D executives met at our Research Xchange Forum on Oncology in February 2017. Get impressions and insights of our 2 days conference

View Forum

Related topics: Liquid Handling/Pipetting

11/2016

The Role of Pipetting Tips in Achieving the Best Pipetting Performance

This article reports the results of pipette performance testing using different pipette tips, including tips from pipette manufacturers and those from so-called universal tip manufacturers.

View Application Note

Related topics: Oncology, Immuno-Oncology, Cell Analytics

8/2016

MD Anderson Webinar: Improving Analysis of CAR T-Cell Function through High-Throughput Multi-Parameter Flow Cytometry

Get introduced to a non-radioactive assay for rapid and simultaneous assessment of multiple cytotoxic processes in suspensions of target and effector cells by multi-parametric high-throughput flow cytometry.

Author: Tamara Jatoba Laskowski

View Webinar

Related topics: Lab Weighing, GxP Compliant Weighing

3/2016

Determination of the Working Range of the Laboratory Balance According To USP Chapter <41> With USP V2.0

Cubis Q-App USP 2.0 and SQmin function provide secure solutions for weighing in regulated environments in compliance with the new USP Chapter <41> asking for the determination of the working range.

View White Paper

Related topics: Lab Weighing, GxP Compliant Weighing

3/2016

Laboratory Balances of the Cubis Balance Range Meet the Requirements of the Pharmaceutical Industry for Cleanability

Cubis lab balances featuring “Advanced Pharma Compliance” design and function package ensure convenient and efficient cleaning for use in GMP and GLP regulated environments.

View White Paper

Related topics: Viral Therapeutics Development

2/2016

Rapid and Direct Quantification of Viral Vector Particles for Gene Therapy

ViroTag Allows Biologically Relevant In-Process Monitoring of Total Particle Count

Author: Michael Artinger, Rebecca Montange, Michael W. Olszowy

View Article

Related topics: Filtration, Protein Concentration & Purification

2/2016

Vivaflow® and Vivaspin® Workflow in Protein Research Laboratories

Concentration and Purification of Proteins in Cell Culture Supernatant Using Sartorius Vivaflow, Vivaspin and Vivapure Products

View Application Note

Related topics: Filtration, Protein Concentration & Purification

Related topics: Filtration, Sample Preparation, DNA Concentration & Purification

2/2016

Primer removal after a PCR reaction with Vivacon® 500

Method to effectively remove primers and PCR reaction components that may interfere with subsequent applications from PCR samples using Vivacon® 500 ultrafiltration devices.

View Application Note

Related topics: Filtration, Protein Concentration & Purification

2/2016

Desalting and Buffer Exchange with Vivaspin® Centrifugal Concentrators

Application of Vivaspin centrifugal concentrators for fast filtration of target proteins with high recovery rates in desalting or buffer exchange.

Author: Pieter Eyckermann, Rik McRae, Andreas Kocourek, Robert Zeidler

View Application Note

Related topics: Filtration, DNA Concentration & Purification

2/2016

Treatment of Vivaspin® concentrators for improved recovery of low-concentrated protein samples

Introduction to a pretreatment procedure for Vivaspin® concentrators that improves the recovery of concentrated protein samples in the nano- to microgram concentration range to >90%.

Author: Rik McRae, Claudia Naumann, Kristin Hoehne, Robert Zeidler

View Application Note

Products:
Vivaspin®

Related topics: Filtration, Sample Preparation, Protein Concentration & Purification

2/2016

Filter Aided Sample Preparation (FASP) with Vivacon® 500

FASP-based application for gel-free buffer exchange and peptide fractionation from biological samples using Vivacon® 500 filtration units.

View Application Note

Related topics: Protein Expression

2016

Direct, Real-Time, Antibody-Based Quantification of Baculovirus

Get introduced to the unique ViroTag® system facilitating rapid and specific real-time in-process monitoring and quantification of viruses and virus-related particles with fluorescently tagged antibodies.

Author: Michael Artinger, April Birch, Tyler Gates, Christopher Kemp, Michael W. Olszowy

View Article

Related topics: Oncology, Immuno-Oncology, Antibody Discovery, Small Molecule Drug Discovery, Antibody Discovery, Cell Analytics

2016

SLAS 2016 Phenomenal Spectral Bandwith .. Minimal Assay Volumes! Introducing iQue Screener PLUS

This tutorial highlights the ability of the iQue Screener PLUS to expand the envelope of true immunology screening by combining immunophenotyping, cell health, cell function, and cytokine profiling into single high content assays for immuno-oncology, immune targets, and antibody screening applications.

Author: Joseph Zock

View Event Talk

Related topics: Small Molecule Drug Discovery, Cell Analytics

2016

Next Generation Phenotypic Screening

Brief review summing up the limits of target-based approaches and the advantages of next generation phenotypic screening technologies in the large scale industrial discovery of first-in-class small-molecule drugs.

View White Paper

Related topics: Filtration, Protein Concentration & Purification

2016

Scouting Protein Purification Conditions Using Vivapure Centrifugal Ion Exchange Membrane Absorbers

Introduction to a spin column-based approach for separation and purification of target proteins from biological samples by use of several specific Vivapure Centrifugal Ion Exchange Membrane Absorbers.

Author: C. Naumann, N. Kashani-Poor

View Application Note

Related topics: Oncology, Immuno-Oncology, Cell Analytics

11/2015

ImmunXperts Webinar: Use of the iQue Screener as a versatile tool for in-vitro immunogenicity and immunotoxity risk assessment

Find out how to conduct preclinical immunogenicity risk assessment assays at a much higher throughput and with much lower sample volumes by using the reliable and robust iQue Screener flow cytometry platform.

Author: Brecht Hoedemaekers

View Webinar

Related topics: Oncology, Immuno-Oncology, Cell Analytics

11/2015

High Throughput Flow Cytometry Applications for the Discovery of Therapeutics in Oncology and Immunology

Compelling overview presenting the capabilities of iQue Screener in diverse assays for large scale multiplexed assessment of the effects of potential therapeutics on cells and proteins in suspension.

Author: Thomas D.Duensing

View Webinar

Related topics: Filtration, Protein Concentration & Purification

11/2015

Vivaspin® Turbo 4 Ultrafiltration – An Economic and Ergonomic Approach to Separate Proteins & Metabolites for Disease Detection

Approach to separate proteins and biomolecules based on their molecular weight by using Vivaspin® Turbo 4 Ultrafiltration spin columns with membranes that provide specific molecular weight based retention rating.

Author: Dr. Ashish Gupta

View Application Note

Products:
Vivaspin® Turbo 4

Related topics: Oncology, Immuno-Oncology, Antibody Discovery, Cell Analytics

10/2015

Avacta Webinar: Rapid Identification and characterization of Affimers, a novel antibody mimetic using the iQue platform

Become acquainted with affimers, their impact in research and diagnostics, and the efficiency of iQue Screener in high-throughput screening of affimer libraries for cross reactive binders to immune checkpoint inhibitors.

Author: Matt Johnson

View Webinar

Related topics: Protein Expression

10/2015

Biogen Presentation: "Streamlining Baculovirus Workflow with ViroCyt Virus Counter 3100"

Presentation and discussion of data demonstrating that incorporating ViroCyt Virus Counter into virus-based protein expression workflows greatly enhances efficiency.

Author: Dr. Mia Rushe

View Application Video

Related topics: Viral Therapeutics Development

10/2015

Real-Time Virus Quantification Using Direct Affinity-Based Detection

See how the ViroCyt® Virus Counter system specifically addresses the challenge of detecting small particles and why data collected with Virus Counter are more biologically relevant.

Author: Dr. Michael Olszowy

View Application Video

Products:
Virus Counter®

Related topics: Vaccine Production

10/2015

Sanofi Pasteur: Accelerating Viral Vaccines Process Development

Compelling presentation of the various steps in vaccine development including methods for vaccine analytics and introduction to the manifold benefits of employing Virus Counter in viral vaccines process development.

Author: Danny Vellom

View Event Talk

Related topics: Lab Water Purification

10/2015

arium® Water Purification Terms

Detailed A-Z listing and explanation of terms, abbreviations, and technical terms related to water purification and arium® Lab Water Systems.

View Brochure

Related topics: Viral Therapeutics Development

10/2015

Real-Time Virus Quantification Using Direct Affinity-Based Detection

See how the ViroCyt® Virus Counter system specifically addresses the challenge of detecting small particles and why data collected with Virus Counter are more biologically relevant.

Author: Dr. Michael Olszowy

View Application Video

Related topics: Microbiological Analysis, Microbiological Enumeration

9/2015

Microbiological Testing Using Nutrient Pad Sets for Quality Assurance of Beverages

Introduction to Nutrient Pad Sets - the superior membrane filtration method for microbiological testing in Quality Assurance of beverages.

Author: Juliane Pfützenreuter (Sartorius)

View Article

Related topics: Oncology, Immuno-Oncology, Small Molecule Drug Discovery, Antibody Discovery, Cell Analytics

8/2015

Immunology Screening on the iQue Screener: Assays for Immune-Modulators and Immunotherapy

See how to run assays for cell proliferation, immunophenotyping, cytokine profiling and cytotoxicity in large multiplexed experiments by employing the unique capabilities of the high-throughput iQue Screener platform.

Author: Robbie Narang

View Webinar

Related topics: Liquid Handling/Pipetting

8/2015

Low Retention Tips FAQ

Collection of facts and recommendations on the characteristics, possibilities of application, and practical use of Low Retention Tips for professional pipetting.

View Article

Related topics: Liquid Handling/Pipetting

8/2015

Work More, Hurt Less

Discussion of advantages of electronic pipettes in ergonomics and efficiency, presentation of Picus Electronic Pipettes and introduction to Pipetting Academy training program.

Author: Matthias Beuse

View Article

Related topics: Liquid Handling/Pipetting

7/2015

How to Select a Mechanical Pipette

Factors to be considered when selecting a mechanical pipette for professional laboratory work.

View Application Note

Related topics: Lab Weighing, GxP Compliant Weighing

6/2015

GxP-compliant Printing and Archiving of Initial Weights and Related Weighing Data

Introduction to thermal printing processes and YDP30 premium label printer ideal for GxP-compliant documentation in GxP-regulated environments.

View White Paper

Related topics: Lab Water Purification, Ultrapure Water, Pure Water

6/2015

arium® Lab Water Systems - Inspired by Your Applications

Get yourself introduced to the arium® Lab Water Systems product family and arium® bagtank system, its technical features and integrated software applications for optimizing water usage.

View Application Video

Related topics: Microbiological Analysis, Mycoplasma Contamination Control

5/2015

Benchmarking of the Microsart AMP Mycoplasma kit with products of two other suppliers

In these studies Sartorius Microsart® AMP Extraction und Microsart® AMP Mycoplasma were benchmarked with Mycoplasma Real-time PCR kits incl. sample preparation of two other suppliers.

Author: Alexandra Scholz (Sartorius) Stephanie Schweizer (Sartorius)

View Application Note

Related topics: Protein Expression

5/2015

Improving Pace & Efficiency of Protein Expression Using Baculovirus-Based Systems

Get and in-depth demonstration of the unique capabilities of the ViroCyt Virus Counter 3100 system and see how applying real-time total particle determination to virus-based systems is beneficial to recombinant protein production.

Author: Dr. Mike Olszowy and Dr. Chris Kemp

View Webinar

Related topics: Liquid Handling/Pipetting

5/2015

Low Retention Tips Performance comparison of low retention pipette tips from various manufacturers

Pipetting accuracy and precision are the key factors for successful experiments in the laboratory. The best pipetting performance is achieved, when the pipette and the tip match perfectly with each other, and the tip being used is optimal for the liquid being transferred.

View Application Note

Related topics: Viral Therapeutics Development

4/2015

Virotherapy Process Optimization

Brief discussion on how the real-time enumeration of viruses facilitated by the ViroCyt® Virus Counter® 3100 can significantly enhance the pace of virotherapy product development.

Author: Michael Artinger

View White Paper

Related topics: Filtration, Protein Concentration & Purification

4/2015

Urine Protein Concentration with Vivaspin® Concentrators

Describes the application of Vivaspin® centrifugal concentrators for urine concentration prior to measurements of protein in diagnosis and monitoring of diseases and disorders.

Author: Bob Tutunjian

View Application Note

Related topics: Lab Weighing, GxP Compliant Weighing

3/2015

Compliance with Requirements for the Weighing Chamber

Discussion of environmental conditions and technical requirements to be considered for GxP-compliant weighing and introduction to technical features that ensure secure weighing with Cubis® balances.

View White Paper

Related topics: Lab Weighing, GxP Compliant Weighing

3/2015

Weighing Subject to the Requirements of "Good Manufacturing Practices" (GMP) - a Task for the Analytical Balance MSA125P-100-DI

Cubis MSA125P-100-DI analytical balance - particularly developed for GMP or GxP applications in the highly regulated environment of pharmaceutical industry.

View White Paper

Related topics: Small Molecule Drug Discovery, Cell Analytics

2/2015

SLAS 2015 UCB: Incorporating the iQue Screener into a Fully Automated Screening Platform

Learn about the experiences with and benefits of incorporating the iQue Screener into an automated flow cytometry workcell to facilitate high content profiling of novel therapeutics in a high throughput format.

Author: Kevin Whale

View Event Talk

Products:
iQue® Screener

Related topics: Small Molecule Drug Discovery, Cell Analytics

1/2015

3-Dimensional Multiplexed Analysis of Cells and Secreted Proteins for Rich Content in Context

Come to know the exciting possibilities opened up for high content screening by 3-D multiplexing presented in a case study and facilitated by IntelliCyt’s established or custom-build integrated screening solutions.

Author: Scott Perschke

View Webinar

Related topics: Microbiological Analysis, Microbiological Enumeration

1/2015

Rapid & easy solution for reliable mycoplasma contamination control

Rapid real-time PCR test kits for the detection of mycoplasma contaminations in cell culture media, mammalian cell cultures and cell culture supernatants, or cell-culture derived biologicals for lot release.

View Application Video

Related topics: Protein Expression

1/2015

Optimizing Virus-Based Expression Systems

Learn about analytical platform designed to improve direct virus quantification and optimized for real-time, in-process quantitation with the potential to transform and speed up bioprocessing of virus-derived systems.

Author: Michael Artinger, Christopher W. Kemp, Peter Pushko, Michael W. Olszowy

View Article

Related topics: Lab Water Purification, Ultrapure Water, Pure Water

1/2015

Pure Water: The Most Essential Laboratory Element

Introduction to application-tailored labwater purification systems, beneficial water purification system features, and specifications for pure water standards.

Author: Frank Gatzemeyer

View Article

Related topics: Oncology, Immuno-Oncology, Antibody Discovery, Cell Analytics

2015

Immuno-oncology Profiling for Drug Discovery and Translational Reserach

Learn about the latest developments in immuno-oncology discovery and powerful tools for suspension-cell analysis to advance immunology and immune-oncology profiling for drug discovery and translational research.

View eBook

Related topics: Oncology, Immuno-Oncology, Small Molecule Drug Discovery, Cell Analytics

2015

ImVacs 2015: High Throughput Flow Screening Assays to Profile Cell-Mediated Killing

This multiplex high throughput screening assay facilitates rapid and flexible assessment of cell mediated killing by analyzing target and effector cell populations at the same time.

Author: Wade Johnson, Robbie Narang, Kim Luu

View Poster

Related topics: Oncology, Immuno-Oncology, Small Molecule Drug Discovery, Cell Analytics

2015

ECI 2015: High Throughput Flow Screening Assays for Immune Checkpoint Inhibitors: Example Assays for PDL1/2 Functional Blocking Antibodies

iQue Screener and MultiCyt QBeads facilitate simultaneous measurement of immune cell function endpoints and secreted cytokine levels in a robust high throughput assay.

Author: Zhaoping Liu, Thomas Duensing, Kim Luu

View Poster

Related topics: Oncology, Immuno-Oncology, Small Molecule Drug Discovery, Cell Analytics

2015

SLAS 2015 Edge Labs: Speed and Sensitivity - The Special Advantages of High Throughtput Cytometry for Cell Surface Protein Trafficking Assays

Imaging versus cytometry - learn about the Fluorogen Activating Peptide technology and the advantages of integrating the iQue Screener in screening assays for the identification of compounds capable of CFTR restoration.

Author: Scott Sneddon

View Event Talk

Related topics: Small Molecule Drug Discovery, Cell Analytics

2015

Multiplexed Detection of Mouse Cytokines Using QBeads and the iQue Screener

Rodent cytokine quantification using QBeads on iQue Screener offer three important benefits for screening: multiplexed no-wash protocols, compatibility with a high degree of assay miniaturization, and rapid plate sampling speeds.

View Application Note

Related topics: Small Molecule Drug Discovery, Cell Analytics

2015

Comparison of Luminex 100 and iQue Screener using Qbeads

Get to know the advantages of MultiCyt QBeads on iQue Screener for detection of secreted proteins by bead-based ELISAs: significantly easier, more economical, and much more affordable.

View Application Note

Related topics: Small Molecule Drug Discovery, Cell Analytics

2015

AAI 2015: Profiling a Structure Activity Relationship (SAR) Library for Immunological Activity in Human PBMCs

iQue Screener is perfectly optimized for multiplexed measurements of cell phenotype, viability, and cytokine secretion from one single no-wash high throughput assay aimed at identifying putative immune-modulatory compounds.

Author: Thomas Duensing, Daniela Brodbeck, Serge Parel, Zhaoping Liu, Kim Luu

View Poster

Related topics: Small Molecule Drug Discovery, Cell Analytics

2015

ECI 2015: Phenotypic screenings to discover novel immunoregulators to treat inflammatory diseases

Presentation of successful identification of small molecules with immunoregulatory capacity by well-established phenotypic screening methods using multiplexed, no wash, high throughput flow cytometer readouts.

Author: Stefan Frischbutter, Olga Trupp, Anja Schaus, Van Duc Dang, Imme Sakwa, Simon Fillatreau, Alf Hamann

View Poster

Related topics: Small Molecule Drug Discovery, Cell Analytics

2015

Profiling of a compound library biased toward immunomodulating agents: multiplexed measurements of cell phenotype, viability and cytokine secretion of human PBMCs

Conclusive step-by-step presentation of screening compounds for their potential to modulate immune reactions in a multiplexed, no wash, high throughput workflow performed with the iQue Screener platform.

Author: Serge P. Parel, Laurent Brault, Tom Duensing, Zhaoping Liu, Kim Luu, Daniela Brodbeck

View Poster

Related topics: Small Molecule Drug Discovery, Cell Analytics

2015

HCA 2015: Simultaneous Profiling of B Cell Health and Cytokine Secretation in a No-wash Assay by High Throughput Flow Cytometry

The iQue Screener platforms meets the unique demands of high content, high throughput screening of immune cells in suspension by facilitating simultaneous detection of the cells themselves, as well as the cytokines secreted.

Author: Zhaoping Liu, Kim Luu

View Poster

Related topics: Small Molecule Drug Discovery, Cell Analytics

2015

SLAS 2015: Miniaturization og High Throughput Flow Assays for 384-Well Low Volume and 1536-Well Plates: Detection of Multiplxed Analytes in 6 uL Assays with the iQue Screener and MultiCyt Qbeads

Learn how using the iQue Screener for multiplexed high throughput screening of suspension samples can significantly lower your costs by working with very small sample volumes without sacrificing data quality.

Author: Robbie Narang, Wade Johnson, Kim Luu

View Poster

Related topics: Small Molecule Drug Discovery, Cell Analytics

2015

SLAS 2015: Utilizing High Throughput Flow to Screen for Differential Sensitivity of primary Cells to Immunosuppressive Compounds

See data demonstrating the unique ability of the iQue Screener to analyze compound immunotoxicity to primary cells in suspension by multiplexed assays in a miniaturized, no-wash assay, high throughput workflow.

Author: Zhaoping Liu, Robbie Narang, Kim Luu

View Poster

Related topics: Small Molecule Drug Discovery, Cell Analytics

2015

SLAS 2015 AbbVie: Application of Multiplex Apoptosis Screening Assay to Access the Mechanism of Action of CDK9 Inhibitors Using High Throughout Flow Cytometry

Application of a multi-parameter, high throughput flow cytometry system in apoptosis screening assays increases cost and time efficiency of identifying compounds for treatment of cancer.

Author: Morey Smith

View Event Talk

Products:
iQue® Screener

Related topics: Small Molecule Drug Discovery, Cell Analytics

2015

IntelliCyt & LabCyte Webinar: High Content High Throughtput Cell Health and Cell Function Assays

See studies that showcase the opportunities provided by novel technologies developed for measurement of multiple parameters simultaneously and thereby maximize the contextual and correlative value of screening data.

View Webinar

Related topics: Antibody Discovery, Cell Analytics

2015

Agensys Webinar: Accelerated Antibody Discovery

Why employ the iQue screener platform into hybridoma and monoclonal antibody screenings? This presentation gives you a comprehensive summary of screening techniques and the unique capabilities of iQue Screener.

View Webinar

Related topics: Filtration, Protein Concentration & Purification

12/2014

High Recovery of Cationised Protein in Centrisart® I

Purification and concentration of isolated and positively-supercharged proteins by ultracentrifugation using Centrisart® I results in faster process time and highly increased protein yield.

Author: Ben Carter, Ben Williams

View Application Note

Products:
Centrisart® I

Related topics: Lab Water Purification, Ultrapure Water

12/2014

Signaling Substances Used in Plant Defense: HPLC-MS/MS Analysis of Jasmonates

Ultrapure water produced with the arium® pro VF TOC system is readily suitable for use in quantitative analysis of phytohormones in the picomolar concentration range by HPLC-MS.

Author: Tim Iven, Kirstin Feussner, Cornelia Herrfurth, Elmar Herbig

View Article

Related topics: Small Molecule Drug Discovery, Cell Analytics

11/2014

Pfizer Webinar: Just-In-Time Live Cell Throughput Flow cytometry - Assay Development and Automation Integration for 384 Well screening Assay

Partake in the development of a miniaturized and industrialized high content, multi-parameter screening assay to profile pharmacological chaperone activity, compound toxicity and cell surface receptor expression changes.

View Webinar

Related topics: Antibody Discovery, Cell Analytics

11/2014

A Novel, No Wash Screening Assay to Simultaneously Measure Binding to Target and Control Antigens on Mammalian Cell Surfaces

Introduction to a mix and read screening workflow facilitating simultaneous testing of antibody binding to both target and control antigens on the cells surface by a multiplexed HTFC hybridoma screening assay.

Author: Yen Kim Luu, Zhaoping Liu, Mara Abashian and Thomas D. Duensing

View Poster

Related topics: Antibody Discovery, Cell Analytics

10/2014

MorphoSys Webinar: Identification of Antibodies against Challanging Targets using High Throughput, Multiplexed Approaches

Antibody-based therapeutics are unique in that they are specific in terms of binding to their target antigen. Evaluation of cross-species and/or epitope reactivity of antibodies during the screening phase is of high importance.

This webinar overviews:
• The evaluation of cross species reactivity of antibodies in the primary screening phase using the IntelliCyt platform
• Applications of the IntelliCyt platform in different phases of the drug discovery process

Author: Dr. Markus Waldhuber

View Webinar

Related topics: Protein Expression

9/2014

Real-Time Baculovirus Quantification with Virus Counter

Gain valuable insights into the advantages of rapid viral particle quantification for baculovirus-based expression systems through real-time determination of total intact particle count facilitated by ViroCyt Virus Counter.

View White Paper

Related topics: Viral Therapeutics Development

9/2014

Why Viral Particle Quantification Matters

Learn about the biological significance of non-infectious viral particles and why it is of particular importance to determine the total number of viral particles in a virus containing sample.

View White Paper

Related topics: Vaccine Production

9/2014

Rapid Quantification of Egg-Grown Influenza

Overcoming the bottleneck of virus quantification along the vaccine development and manufacturing process by applying the unique capabilities of the ViroCyt Virus Counter to facilitate real-time enumeration of viral particles.

View White Paper

Related topics: Viral Therapeutics Development

8/2014

An Overview of Virus Quantification Techniques

Extensive summary and discussion of the different approaches commonly used to quantify virus by measurement of viral infection, viral protein antigens or expression levels of viral genes, and directly counting viral particles.

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Related topics: Liquid Handling/Pipetting

8/2014

Pipetting Academy - Pipette Calibration

Provides valuable information on equipment, procedures, and environmental factors to ensure pipette calibration processes are being performed to achieve maximum pipetting reliability and accuracy.

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Related topics: Filtration, Protein Concentration & Purification, Virus Concentration & Purification

8/2014

Vivaflow 200 | The Lab Crossflow Device

Vivaflow 200 is a ready to use and reusable laboratory crossflow cassette for concentrating up to 5 l samples.

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Related topics: Small Molecule Drug Discovery, Cell Analytics

7/2014

Less is More: Redefining High Throughput Flow and the Value of Suspension Screening

iQue Screener overcomes the challenge of analyzing both cells and secreted proteins in the same well by facilitating multiplexed screening – see case studies of immunophenotyping and cytokine profiling assays.

Author: Joe Zock

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Related topics: Oncology, Immuno-Oncology, Small Molecule Drug Discovery, Cell Analytics

6/2014

High Throughput Flow - Enabling Multiplexed, Miniaturized, High Throughput Cell-and Bead-Based Assays

Flow cytometry is an attractive technique for suspension based assays – learn how IntelliCyt has further optimized this technology to facilitate a broad range of cell health profiling assays on physiologically relevant samples.

Author: Steve Davenport, Robbie Narang

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Related topics: Small Molecule Drug Discovery, Cell Analytics

6/2014

Cells, Beads & More: The New Role of Suspended Assay Formats in Phenotypic Screening

See various examples of how IntelliCyt’s integrated screening solutions facilitate simple implementation of high throughput, high content phenotypic screening of suspended and suspendable cells, beads, and mixtures.

Author: Joseph M. Zock

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Related topics: Lab Water Purification, Ultrapure Water

6/2014

arium® Lab Water Systems - Designed to Deliver Pure Performance

Presentation of the arium® pro VF system for production of ultrapure water and its technical features ensuring highest water quality and process reliability for research and analytical laboratories.

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Related topics: Microbiological Analysis, Microbiological Enumeration

5/2014

Prevention Instead of Decontamination - From Filtration to Incubation in Microbiological Quality Control

The touch-free agar and membrane transfer concept of Microsart® @media dishes and @filter units provides a beneficial method for microbial enumeration in microbiological quality control.

Author: Jasmin Grigat

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Related topics: Small Molecule Drug Discovery, Cell Analytics

3/2014

Secretome Screening with MultiCyt Qbeads

Revolutionize your screening approach with the MultiCyt QBeads product family prodising a very easy and very fast way to measure multiple secreted proteins simultaneously.

Author: Scott Perschke

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Related topics: Protein Expression

2/2014

Cost Savings of Rapid Baculovirus Quantification

Comprehensive ROI analysis demonstrating the significant benefits of replacing cumbersome plaque titer assays with the time and cost effective solution of applying the ViroCyt Virus Counter in viral quantification.

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Related topics: Filtration, Virus Concentration & Purification

2/2014

Depyrogenation of Vivaspin® Turbo 15 in comparison to Ultrafiltration devices with a regenerated cellulose membrane

Description of a method for fast and reliable depyrogenation of Vivaspin® Turbo 15 devices for use in applications in which the absence of bacterial endotoxins is essential.

Author: Husna Begum, Mike Brownleader, Ben Williams

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Related topics: Oncology, Immuno-Oncology, Small Molecule Drug Discovery, Cell Analytics

2014

Development of a No-Wash 4-Plex Apoptosis Screening Kit and Validation for Phenotypic Screening

Quick and convenient determination of apoptotic processes by simultaneous detection of four well-established apoptosis markers in a single validated and easy-to-use multiplex assay.

Author: Robbie Narang, Zhaoping Liu, Kim Luu

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Related topics: Oncology, Immuno-Oncology, Cell Analytics

2014

Cells and Beads Together Simultaneous Analysis of Secreted Il-2 and Jurkat Cells

In combination, QBeads&trade; PlexScreen kits and the iQue Screener facilitate simultaneous analysis of immune cells and bead-based screening of any of 50 human secreted proteins in a convenient no wash assay protocol.

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Related topics: Oncology, Immuno-Oncology, Cell Analytics

Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

Application of MultiCyt Qbeads

Application of MultiCyt QBeads for High Throughput Cytokine Profiling in Human Peripheral Blood Mononuclear Cells

Author: Robbie Narang, Zhaoping Liu, Kim Luu

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

High Throughput Flow Assays using the MultiCyt Cell Proliferation Reagent Dye Panel

Multiplexing with Membrane Integrity, Cell Cycle and Immunophenotyping Endpoints

Author: Robbie Narang, Zhaoping Liu, Kim Luu

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

Multiplexing Secreted Protein Screening, Proliferation And Immunophenotyping of PBMCs on the iQue Screener

The iQue platform facilitates rapid high content multiparametric screening assays for measurement of T-cell activation by multiplexed cell and bead based readouts using cell suspensions.

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

Comparison of MSD and IntelliCyt Qbeads PlexScreen for Screening Secreted Proteins

Highly flexible multiplex assays, quick and convenient no wash protocols, cost and time effective high throughput analysis - screening of secreted proteins by pairing of QBeads and the iQue® Screener proofs superior by all means.

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

Determing Absolute Counts on iQue Screener

iQue® Screener facilitates accurate sample volume measurement, determination of absolute cell counts per well, and thereby quantification of secreted proteins on a per cell basis – in one straight forward multi-parameter assay.

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

Low Cost Assays on the iQue HD

iQue® HD stands for: assaying objects, cells and secreted proteins in suspension by an affordable, multi-parameter, no wash, high throughput protocol capable of cost and time effective 1536-well screenings.

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

How and When Markers Can Make a Better Assay

Find out why and how IntelliCyts’ in-well and between well marker solutions facilitate accurate screening of no or low object count samples and ensure detection and analysis of all data is included in “long sip” assays.

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

Profiling Immunosuppressants in Primary Human PBMC's on the iQue Screener

Leverage the unique iQue Screener’s capabilities of simultaneously profiling cell proliferation and cell viability in multiplexed no-wash assays revealing the effects of immunosuppressants on primary immune system cells.

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

Rare T-Cell Subpopulation Screening

See how iQue Screener passed the challenge of precisely detecting rare cell subpopulations with flying colors and benefit from the protocol particularly developed to ensure statistical significance while providing much faster throughput.

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Products:
iQue® Screener

Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

Screening Microorganisms on the iQue Screener

Get introduced to the immense number of applications the iQue Screener provides for analyzing diverse microorganisms, monitoring growth and productivity, and screening for anti-tag antibodies and protein-protein interactions.

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

ELRIG 2014: The iQue Platform Enables Simultaneous Measurement of Beads and Cells in a Single Assay: Profiling of Cytokine Secretion, Cell Phenotype and Proliferation in a PBMC Model

Maximize the contextual and correlative value of your screenings by multiparameter measurements of cytokine secretion, cell proliferation and cell phenotypes using the iQue Screener platform.

Author: Ann Lu and Zhaoping Liu

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

ELRIG 2014: High Throughput Multiplexed Apoptosis Assays Using the Labcyte echo Liquid Handler and the IntelliCyt iQue Screener HD

Combining MultiCyt Apoptosis Screening kit, Echo liquid handler and iQue Screener HD enables cost and time effective, minimal volume, and multiplexed high throughput apoptosis assays.

Author: Dominik Zahr, Carl Jarman, Bonnie Edwards, Helen Ho* and John Lesnick

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

PEGS China 2014: Development Of A Multiplex High Throughput Screening Assay Cascade For Evaluating Receptor Tyrosine Kinase Binding And Activation

Accelerate your therapeutic antibody development process by application of the presented workflow for detection of protein based therapeutics in multiplexed cell based assays using the iQue Screener.

Author: Thomas D. Duensing, Zhaoping Liu, and Yen Kim Luu

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

High Content in Suspension: No-Wash Multiplexed Cytokine Profiling of Human Peripheral Blood Mononuclear Cells (PBMCs)

Learn how to elevate the detection of secreted proteins to an unprecedented level of cost and time efficiency by performing your screening assays with MultiCyt QBeads.

Author: Michael D Sjaastad, Robbie Narang, Kim Luu

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

SLAS 2014: Rapid Profiling of Compounds for Cell Cycle and Apoptosis: Using Single Micro-Scale Compound Treatments for Multiple Multiplexed Assays

See how compound profiling with iQue Screener technology proves highly cost and time efficient in multiparameter, high throughput phenotypic screening assays of cells in suspension.

Author: Robbie Narang, Daniela Brodbeck, Serge Parel, Kim Luu

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

User Group Meeting 2014 Bristol-Myers Squibb: Developing a High Throughput Solubility Assay Using the IntelliCyt iQue Screener

See for yourself why iQue Screener came out first in an investigation of new instrument systems facilitating reliable high throughput aqueous compatibility assays plus additional valuable applications.

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

Koch Institute Webinar: Predicting Mechanisms of Action of Cytotoxic Compunds using shRNA Technology on the iQue Screener

Integrating the iQue Screener platform into studying the molecular mechanism of action of cytotoxic drugs allows high throughput screening of large compound libraries and systematic profiling of responses to drug combinations.

Author: Peter Bruno

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Related topics: Antibody Discovery, Cell Analytics

2014

Better Antibody Screening using IntelliCyt's iQue Screener

Learn about the advantages of employing iQue Screener in your antibody discovery workflow: time-saving no-wash protocol, minimal assay volumes, rapid sample analysis, and detection of low affinity binders.

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Related topics: Antibody Discovery, Cell Analytics

2014

Protein Screening using Yeast 2-Hybrid System

Employing iQue Screener in Yeast 2-Hybrid assays facilitates simultaneous multiple parameter screenings of cell viability, ploidy, and protein-protein or protein-DNA interactions through detection of reporter gene expression.

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Related topics: Protein Expression

2014

Rapid and Effective Monitoring of baculovirus Concentrations in Bioprocess Fluid Using the ViroCyt Virus Counter

See how you can benefit from the advantages of employing the ViroCyt Virus Counter in bioprocessing of virus-derived systems to gain reliable, close to real-time estimates of total and infectious virus particle counts.

Author: April Birch, Heather Allen, Kerrie Kennefick, Anita Gugel, Christopher W. Kemp

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Related topics: Filtration, Virus Concentration & Purification

2014

Removal of Endotoxin from Monoclonal Antibodies

Introduction of Vivapure centrifugal anion exchange membrane devices as application for removal of endotoxin from research grade monoclonal antibody solutions with high protein recovery.

Author: Brendan Fish, Karen Bannister, Emma Tribbekk

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2014

Autophagy Screening on iQue

Using Enzo’s Cyto-ID Autophagy Detection kit on the iQue Screener in a rapid no wash screenready assay is a fast and easy way to detect modulators of autophagy in both adherent and suspension cells.

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Related topics: Microbiological Analysis, Microbiological Enumeration

12/2013

Biosart® 100 Monitors and Media - Monitoring the quality of water and beverages

Biosart® 100 Monitors in combination with Nutrient Media for efficient application in high throughput microbiological testing of pharmaceuticals, food, beverages, water and other liquids.

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Related topics: Filtration, Protein Concentration & Purification, Virus Concentration & Purification

12/2013

Vivaflow 50R plug and play Crossflow Unit for 100 ml to 1 liter samples

Vivaflow 50R is a ready-to-use and reusable laboratory crossflow cassette for concentrating up to 1 l samples. The active membrane area per device is 50 cm².

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Products:
Vivaflow® 50R

Related topics: Liquid Handling/Pipetting

11/2013

Low Retention Tips

Highlights/Spotlights the hydrophobic surface technology in Sartorius Low Retention Tips and the benefits that ensure effective pipetting of liquids with low surface tension.

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Related topics: Liquid Handling/Pipetting

11/2013

How to improve your pipetting ergonomics

Practical and beneficial recommendations on how to improve pipetting ergonomics to minimize effort and prevent strain.

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Related topics: Microbiological Analysis, Microbiological Enumeration

10/2013

Advanced System for Agar and Membrane transfer: Microsart @media @filter

Microsart® @media dishes and @filter units provide a touch-free agar and membrane transfer concept for microbial limit testing of pharmaceutical and biotech products.

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Related topics: Filtration, Sample Preparation

10/2013

The Measurement of Soluble (< 10 kDa) Trace Metals in seawater by the Vivaflow 50

Introduction to a procedure for the determination of soluble (< 10 kDa) iron in seawater using ultrafiltration with the Vivaflow 50.

Author: Dr. Peter Croot

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Products:
Vivaflow® 50

Related topics: Lab Weighing, GxP Compliant Weighing

Related topics: Lab Weighing, GxP Compliant Weighing

10/2013

Have you heard about the New USP Chapter 41 changes?

Discussion of new USP Chapter 41 changes and introduction to new balance standards implemented in Cubis® to perform accurate measurements and required compliance tests in the pharmaceutical industry.

Author: Dirk Ahlbrecht

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Related topics: Lab Water Purification, Ultrapure Water

9/2013

Flow Cytometry Applied to Plant Reproductive Biology

Arium® pro VF system produces ultrapure water that is a beneficial solution for use in flow cytometric analysis in plant cells.

Author: Diego H. Hojsgaard, Elmar Herbig

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Related topics: Liquid Handling/Pipetting

Related topics: Small Molecule Drug Discovery, Cell Analytics

5/2013

No Wash MultiMetric Apoptosis and Cell Cycle Screening kits Significantly Facilitate Quantitative HTS and Confirm Primary Screening Data

Gaining highest value quality hits in compound library screening and discovery of novel drug combinations in cancer research - see how implementation of IntelliCyt’s multimetric screening kits and qHTS makes it possible.

Author: Lesley Mathews / Tom Duensing

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Related topics: Vaccine Production

4/2013

Sanofi Pasteur: Virus Counter Use for Determining Seed Selection & Viral Yield Information in Upstream Process Steps

Presentation of data on the application and performance of ViroCyt Virus Counter in the roduction of influenza vaccines.

Author: A. Hardy-Boyer, J. Haines

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Related topics: Lab Water Purification, Ultrapure Water

4/2013

HPLC Analysis - The Role of Ultrapure Water

Ultrapure water produced by the Arium pro VF can be used as a beneficial alternative for the mobile phase in HPLC analysis of water-soluble saccharides.

Author: Katrin Toeppner, Elmar Herbig, Dirk Hansen

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Related topics: Small Molecule Drug Discovery, Cell Analytics

3/2013

Janssen Webinar: Funtional Analysis of Human T Cells by high-Throughput Flow Cytometry

See compelling proof of concept demonstrations of the IntelliCyt system facilitating high throughput, high content, multi parameter analysis of functional and phenotypic outcomes after T cell stimulation.

Author: Ben Harman

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Related topics: Antibody Discovery, Cell Analytics

3/2013

SDIX: Webinar Combining DNA Immunization with Multiplexed High Throughput Flow Cytometry to build large libaries of diverse antibodies to transmembrane proteins

From the experiences presented, learn how users benefited from incorporating Multiplexed High Throughput Flow Cytometry into generating high affinity antibodies against fragile native membrane antigen targets.

Author: Michael C. Brown

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Related topics: Lab Water Purification, Ultrapure Water

3/2013

Ultrapure Water Drives RNA Technologies

The use of ultrapure water produced with the arium® pro VF system in RNA research using in situ hybridization ensures contamination-free reliable results.

Author: Frauke Nitzki, Elmar Herbig

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Related topics: Liquid Handling/Pipetting

2/2013

Pipetting Academy - Training for Expertise

Sartorius Pipetting Academy introduces its training courses on main pipetting techniques and ergonomics to maximize users’ pipette handling safety, comfort and productivity.

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Related topics: Lab Weighing, GxP Compliant Weighing

2/2013

Secura - Easy, Reliable Weighing in Regulated Areas

Secura® user interface and integrated applications - intuitive and easy operation combined with accurate and secure weighing in regulated areas.

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2013

MipTec 2013: Identification and profiling of cell cycle-interfering compounds in phenotypic assays using the iQue Screener

Rapid identification and characterization of cell cycle inhibiting compounds in multiplexed phenotypic assays performed with a simple to handle protocols is effectively accomplished by use of iQue Screener technology.

Author: Daniela Brodbeck, Serge Parel, Kim Luu, Tom Duensing, Stephan Fasler

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Related topics: Vaccine Production

2013

Sanofi Pasteur: The Need to Improve: Introducing Innovations in Existing Vaccine Processes

See a compelling discussion on the whys and hows of the necessity for innovation and improvements in vaccine process development and learn about the advantages provided by the novel Virus Counter quantification technique.

Author: Ronald Neeleman

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Related topics: Antibody Discovery, Cell Analytics

11/2012

Antibody Screening

Scientists need powerful tools that can deliver results to fully understand the ability of candidate antibodies to interrupt cellular and molecular processes that lead to disease states.

View White Paper

Related topics: Lab Water Purification, Ultrapure Water

9/2012

Water is Life - Ultra Pure water in Cell Cultivation

Ultrapure water produced by arium® pro UF is excellently suited for PER. C6 EpCAM cell cultivation.

Author: Anil Kumar Rathod, Sheokant Diwakar & Dr. Ashok Mundrigi, Dr. Elmar Herbig

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Products:
arium® pro UV

Related topics: Filtration, Protein Concentration & Purification

7/2012

Concentration to a defined final volume with Vivaspin Turbo 15

Centrifugation method for concentration of sample solutions to reproducible defined finale volumes by use of Vivaspin® Turbo 15.

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Related topics: Liquid Handling/Pipetting

4/2012

Sartorius Picus electronic pipette

Meet Picus - The Red Dot awarded electronic pipette that eases your work load, protects you from injuries by ensuring optimal working posture and allows accurate and precise pipetting results!

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Related topics: Lab Water Purification, Ultrapure Water

4/2012

Ultrapure Water for Trace Analysis with ICP-MS

Ultrapure water produced with the arium pro VF system is well suited for trace analysis by ICP-MS in the pharmaceutical, food and beverage, and environmental industries, and analytical laboratories.

Author: Elmar Herbig, M. Reutz, R. Braitmayer

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Related topics: Liquid Handling/Pipetting

2/2012

#passionforscience - I love my mechanical pipette

Get to know Tacta - The new perfectly balanced mechanical pipette providing comfort of superb ergonomics, safety from contamination, and achievement of reliable results time after time.

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Products:
Tacta

Also interesting:

Related topics: Liquid Handling/Pipetting

2/2012

The Tacta Experience: Perfectly Balanced

Meet the new premium mechanical pipette Tacta with superb comfort and reliability that makes pipetting effortless and safe, while producing accurate and reliable results time after time.

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Related topics: Lab Water Purification, Ultrapure Water

1/2012

Ultrapure Water Ensures Endotoxin Testing

Ultrapure water produced with arium® pro VF System can readily be used in endotoxin testing as detectable concentrations of endotoxin are far below the limits required by the U.S. Pharmacopeia.

Author: Katrin Toeppner, Elmar Herbig

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Related topics: Antibody Discovery

2012

Multiplexed Antibody Characterization

Combinatorial Evaluation of Species Cross-Reactivity Using a High Capacity Flow (HCF) Approach

Author: Susan R. Watson

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2012

Myeloid Progenitor Cell Differentiation

Advantages of the multiplexing capabilities of the HyperCyt high capacity flow screening platform demonstrated for flow cytometry based profiling of small molecule inducers of stem cell differentiation.

Author: Thomas D. Duensing, David B. Sykes

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2012

A High Throughput Screening Assay for Quantifying Micronucleus Induction

This high capacity flow-based micronucleus assay performed on IntelliCyt’s HTFC Screening System takes genotoxic compound screening and assay analysis to an unprecedented level of efficiency, speed and reliability.

Author: Steven Bryce, Jeffrey Bemis, Zhaoping Liu, Kim Luu

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Related topics: Antibody Discovery, Cell Analytics

2012

Better Hybridoma Screening

A Mix-and-Measure Assay for Screening Hybridoma Supernatants on IntelliCyt Platforms

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Related topics: Antibody Discovery, Cell Analytics

2012

High-Throughput Alanine Scan Epitope Mapping Using High Capacity Flow Cytometry

Shotgun Mutagenesis technology combined with HTFC Screening System provides real-world benefits by dramatically increasing the throughput of mutagenesis studies and antibody epitope mapping.

Author: Robbie Narang, Soma Banik

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Related topics: Antibody Discovery, Cell Analytics

2012

Multiplexed Screening for Antibody Production

A Novel Multiplexed Screening Assay for Assessing Productivity of Antibody-Secreting Cell Lines: Simultaneous Measurement of Secreted Protein and Viable Cell Count

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Related topics: Microbiological Analysis, Microbiological Enumeration

Related topics: Lab Weighing, GxP Compliant Weighing

Related topics: Microbiological Analysis, Sterility Testing

11/2010

Microbial Growth after Filtration of Antibiotic Vancomycin Hydrochloride

Presentation of tests proving the desired growth of microorganisms in Sterisart® systems after membrane filtration of the antibiotic Vancomycin Hydrochloride.

Author: Dr. K. Pflanz (Sartorius)

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Related topics: Filtration, Sample Preparation

11/2010

Primer removal after a PCR reaction with Vivacon® 2

Method to effectively remove primers and PCR reaction components that may interfere with subsequent applications from PCR samples using Vivacon® 2 ultrafiltration devices.

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Products:
Vivacon® 2

Related topics: Filtration, DNA Concentration & Purification, Virus Concentration & Purification

6/2010

Virus Purification with Membrane Chromatography

Sartobind Membrane Adsorbers are chromatographic membranes utilized in purification of viruses and virus like particles and for impurity removal from therapeutic proteins.

Author: Miyako Hirai, Stefan Fischer-Fruehholz, Laura Chirica, Suma Ray

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Related topics: Filtration, Protein Concentration & Purification

2010

Concentration of Mammalian Cell Culture Supernatants with Vivaspin® Turbo 15 and Amicon® Ultra-15 Devices

Description of Vivaspin® Turbo 15 ultrafiltration devices as a method for protein concentration that proved superior to Amicon® Ultra-15 Devices in protein recovery rates.

Author: Alan Purvis Joseph Willet

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Related topics: Filtration, Protein Concentration & Purification

2010

Vivaspin® 500 High-cell-density Cultivation of Ultrafiltration: a substitute to lyophilization

Introduction of ultrafiltration using Vivaspin® 500 centrifugal units as a method superior to lyophilization in protein sample concentration, protein purification, and protein reagent preparation.

Author: Prof. Sampa Das, Prithwi Ghosh

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Related topics: Lab Weighing, GxP Compliant Weighing

2010

Application video: percentage

Step-by-step directions for comparing different samples and determining the percent variation from a reference sample by using the ‘percentage’ application provided by Secura®.

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Related topics: Lab Weighing, GxP Compliant Weighing

Related topics: Lab Weighing, GxP Compliant Weighing

Related topics: Lab Weighing, GxP Compliant Weighing

Related topics: Lab Weighing, GxP Compliant Weighing

2010

Application video: unstable conditions

Step-by-step description of weighing under unstable environmental conditions or weighing living animals by using the ‘unstable conditions’ function provided by Secura®.

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Related topics: Lab Weighing, GxP Compliant Weighing

2010

Application video: statistics

Step-by-step introduction to the process of generating statistics and statistical reports on an entire group of samples using the ‘statistics’ application provided by Secura®.

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Related topics: Lab Weighing, GxP Compliant Weighing

2010

Application video: checkweighing

Brief step-by-step description of checking if samples are within a specific tolerance range by using the ‘checkweighing’ function provided by Secura®.

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