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This innovative mix and read screening system combines a convenient 4-plex no-wash staining protocol with a high throughput flow assay for rapid detection of apoptosis in PBMCs.
"Tumor-promoting PRL-3 is suggested as a therapeutic target in cancer cells. Thus, finding inhibitors would be highly desirable. Presented here are findings from studying PRL-3 in epithelial 3D cell culture models and the challenging endeavors of inhibitor development for PRL-3."
Author: Prof. Dr. Maja Köhn
New discoveries in p53 research elucidate that the p53-Mdm2 system provides means to maintain DNA integrity and chromatin stability. These novel activities provide potential targets and opportunities for selectively interfering with tumor cell proliferation.
Author: Prof. Dr. med. Matthias Dobbelstein