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This innovative mix and read screening system combines a convenient 4-plex no-wash staining protocol with a high throughput flow assay for rapid detection of apoptosis in PBMCs.
"Tumor-promoting PRL-3 is suggested as a therapeutic target in cancer cells. Thus, finding inhibitors would be highly desirable. Presented here are findings from studying PRL-3 in epithelial 3D cell culture models and the challenging endeavors of inhibitor development for PRL-3."
Author: Prof. Dr. Maja Köhn
The findings from this trial highlight the multiplicity of mutation-based pathologies and pinpoint novel precision-based therapeutic strategies to pursue for intrahepatic cholangiocarcinoma, and potentially, in future basket trials of diverse tumors using a similar stratification approach.
Author: Assoc. Prof. Dr. Jesper Bøje Andersen