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Related topics: Oncology, Oncology General

2/2017

PRL-3 phosphatase: Roles and targeting in cancer - Lecture Research Xchange Forum 2017

"Tumor-promoting PRL-3 is suggested as a therapeutic target in cancer cells. Thus, finding inhibitors would be highly desirable. Presented here are findings from studying PRL-3 in epithelial 3D cell culture models and the challenging endeavors of inhibitor development for PRL-3."

Author: Prof. Dr. Maja Köhn

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Related topics: Oncology, Immuno-Oncology, Small Molecule Drug Discovery, Cell Analytics

2015

SLAS 2015 Edge Labs: Speed and Sensitivity - The Special Advantages of High Throughtput Cytometry for Cell Surface Protein Trafficking Assays

Imaging versus cytometry - learn about the Fluorogen Activating Peptide technology and the advantages of integrating the iQue Screener in screening assays for the identification of compounds capable of CFTR restoration.

Author: Scott Sneddon

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Related topics: Oncology, Oncology General

2/2017

Genomic Perturbations Reveal Distinct Regulatory Networks in Intrahepatic Cholangiocarcinoma - Lecture Research Xchange Forum 2017

The findings from this trial highlight the multiplicity of mutation-based pathologies and pinpoint novel precision-based therapeutic strategies to pursue for intrahepatic cholangiocarcinoma, and potentially, in future basket trials of diverse tumors using a similar stratification approach.

Author: Assoc. Prof. Dr. Jesper Bøje Andersen

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Related topics: Oncology, Oncology General

2/2017

The p53-Mdm2 system modifies chromatin and DNA replication - Lecture Research Xchange Forum 2017

New discoveries in p53 research elucidate that the p53-Mdm2 system provides means to maintain DNA integrity and chromatin stability. These novel activities provide potential targets and opportunities for selectively interfering with tumor cell proliferation.

Author: Prof. Dr. med. Matthias Dobbelstein

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