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Related topics: Small Molecule Drug Discovery, Cell Analytics

2015

ECI 2015: Phenotypic screenings to discover novel immunoregulators to treat inflammatory diseases

Presentation of successful identification of small molecules with immunoregulatory capacity by well-established phenotypic screening methods using multiplexed, no wash, high throughput flow cytometer readouts.

Author: Stefan Frischbutter, Olga Trupp, Anja Schaus, Van Duc Dang, Imme Sakwa, Simon Fillatreau, Alf Hamann

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2013

MipTec 2013: Identification and profiling of cell cycle-interfering compounds in phenotypic assays using the iQue Screener

Rapid identification and characterization of cell cycle inhibiting compounds in multiplexed phenotypic assays performed with a simple to handle protocols is effectively accomplished by use of iQue Screener technology.

Author: Daniela Brodbeck, Serge Parel, Kim Luu, Tom Duensing, Stephan Fasler

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Related topics: Oncology, Immuno-Oncology, Small Molecule Drug Discovery, Cell Analytics

2014

Development of a No-Wash 4-Plex Apoptosis Screening Kit and Validation for Phenotypic Screening

Quick and convenient determination of apoptotic processes by simultaneous detection of four well-established apoptosis markers in a single validated and easy-to-use multiplex assay.

Author: Robbie Narang, Zhaoping Liu, Kim Luu

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2016

Next Generation Phenotypic Screening

Brief review summing up the limits of target-based approaches and the advantages of next generation phenotypic screening technologies in the large scale industrial discovery of first-in-class small-molecule drugs.

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