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Related topics: Small Molecule Drug Discovery, Cell Analytics

2015

ECI 2015: Phenotypic screenings to discover novel immunoregulators to treat inflammatory diseases

Presentation of successful identification of small molecules with immunoregulatory capacity by well-established phenotypic screening methods using multiplexed, no wash, high throughput flow cytometer readouts.

Author: Stefan Frischbutter, Olga Trupp, Anja Schaus, Van Duc Dang, Imme Sakwa, Simon Fillatreau, Alf Hamann

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Related topics: Small Molecule Drug Discovery, Cell Analytics

6/2014

Cells, Beads & More: The New Role of Suspended Assay Formats in Phenotypic Screening

See various examples of how IntelliCyt’s integrated screening solutions facilitate simple implementation of high throughput, high content phenotypic screening of suspended and suspendable cells, beads, and mixtures.

Author: Joseph M. Zock

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Related topics: Oncology, Immuno-Oncology, Small Molecule Drug Discovery, Cell Analytics

2014

Development of a No-Wash 4-Plex Apoptosis Screening Kit and Validation for Phenotypic Screening

Quick and convenient determination of apoptotic processes by simultaneous detection of four well-established apoptosis markers in a single validated and easy-to-use multiplex assay.

Author: Robbie Narang, Zhaoping Liu, Kim Luu

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Related topics: Small Molecule Drug Discovery, Cell Analytics

2016

Next Generation Phenotypic Screening

Brief review summing up the limits of target-based approaches and the advantages of next generation phenotypic screening technologies in the large scale industrial discovery of first-in-class small-molecule drugs.

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