Upstream & Downstream Technology Forum 2018

Upstream and Downstream Processing: One Common Goal

For over 10 years, the Upstream & Downstream Forum has proven to be an exciting venue for presentations, networking and discussions focusing on the latest applications and technologies.

The event continues to build the collaborative bridge between Upstream & Downstream Bioprocessing by bringing specialists from your peer group who will share their experience by presenting best practices, applications and techniques to address the bottlenecks at the interfaces of upstream and downstream.

June 5 - 7, 2018
Sartorius College
Goettingen, Germany
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Highlights from the European Upstream and Downstream Technology Forum 2016

Don’t miss the Opportunity:

  • To hear about case studies in process development
  • To learn about and discuss the latest advances in upstream and downstream processing
  • To interact with biotech professionals in an exciting and interactive venue format

Highlights of the Agenda 2018

Get insights into the joint development project between Sartorius Stedim Biotech and Amgen
Heather Nunn, Amgen, will talk about the joint development project of ambr® 250 ht perfusion

Dr. Aziz Cayli, PhD, Florabio AS
"They are what they eat – A compendium about the power of cell culture media"

Dr. Lídia Garcia, VMRD Olot, Zoetis Manufacturing & Research, S.L.
"Evaluation of single-use bioreactors to optimize cell growth and scale-up of viral veterinary vaccine production"

Dr. Moritz Bennecke, Roche Diagnostics GmbH
"Virus removal capacity in the downstream process of new format antibodies"

Dan Gibson, GSK
"ambr® crossflow: First impressions of a novel high throughput process development system"

William Man, Genentech
"Scale down capability and benefits for tangential flow filtration"

About Upstream & Downstream Technology Forum

The Upstream Technology Forum has been initiated six years ago to discuss challenges and innovative approaches to cell and microbial culture amongst industry practitioners.

Since 2004 the Downstream Forum provides the latest technical and scientifical approaches in downstream processing to accelerate development and optimize production of vaccines and biopharmaceuticals.

Successful process optimization in upstream has led to increased cell densities and product titers. But what does this mean for downstream processing and purification of the final drug product? These modern, intensified production processes are pushing the bottleneck more and more towards downstream. The need to address this has become stronger than ever before. Following these developments, we started to bring together our established Upstream and Downstream Technology Forum to one joint event.

Venue, Accomodation & Guided Lab Tour

Conference Address

Sartorius College
Otto-Brenner-Strasse 20
37079 Goettingen, Germany

Phone +49-551-308-2101

On the A7 freeway (Hannover- Kassel), take the exit bound for Goettingen Nord (72). Then take the first exit to Industriegebiet (industrial zone) and afterwards, the first exit in the traffic circle. At the next light, make a left turn. Sartorius College will be on your left-hand side.

The nearest airports are Hanover, Kassel and Frankfurt in Germany. From there, you can reach Goettingen by train or car. By taxi, it will take about 10 minutes to get from the Goettingen train station to Sartorius College.

We have arranged limited allotments in the following hotels.
Please mention “Upstream & Downstream Technology Forum” during reservation.

Hotel Rennschuh
Kasseler Landstrasse 93
37081 Goettingen
Phone: +49-551-9009-0
€ 55 incl. breakfast

Park Inn by Radisson Goettingen
Kasseler Landstrasse 25c
37081 Goettingen
Phone +49-551-270707-520
€ 78 Standard room incl. breakfast
€ 113 Suite incl. breakfast


Further recommended hotels where no allotment is reserved but shuttle service to forum venue and evening location will be available nearby:

Novostar Hotel Goettingen
Kasseler Landstrasse 25d
37081 Goettingen
Phone +49-551-99770

Adesso Hotel Schweizer Hof
Kasseler Landstrasse 118
37081 Goettingen
Phone: +49-551-50960

Book a Guided Lab Tour Through the Sartorius Application Center

  • See complete process solutions for upstream and downstream bioprocessing
  • Learn about your options and considerations using single-use systems
  • Highly restricted offer: maximal eight participants to allow hands-on testing
  • Free of charge

Date: Thursday, June 7 | Directly after the end of the forum (around 14:00)
Duration: 90 min
Venue: Science Park, Marie-Curie-Straße 7, 37079 Goettingen

Registration: via email to 


Impressions of Past Forums

The European Forum 2016 took place on June 7 – 9 in the Sartorius College in Goettingen, Germany. It combined a diverse range of lectures and presentations with a focus on: Smart upstream development & scale up, optimizing large scale manufacturing, virus removal trends and challenges.

Cyrus Agarabi, Sr. Regulatory Research | Review Officer, FDA, will present on "Process Analytical Technology (PAT) for Bioprocessing"

Prof Jose C. Menezes, Founder & Managing Director, 4Tune Engineering GmbH, will focus on "Risk Assessment Strategies for Lifecycle Management using Multivariate Data Analysis"

Dr. Horst Ruppach, Global Director, Viral Clearance and Virology, Charles River, will speak about "The viral load and the use of pre-filter in viral clearance studies of virus filtration"

Colin Jaques, Senior Principal Scientist, Lonza Biologics, will talk about “Scale-up in the single use age: Does geometry matter?”

Dr. Berthold Boedeker, Chief Scientist, Global Biological Development WUP, Bayer, will give a lecture on “Single Use Equipment as enabler of ADC conjugation in a standard protein plant using closed systems”

Dr. Jincai Li, Executive Director, Biologics Process Development, Wuxi AppTec Biopharmaceuticals Co., Ltd., China – “Advanced process development using automated micro bioreactors shortens timelines and provides process solutions for a rapid scale up”

Franz Nothelfer, Associate Director Protein Science, Boehringer Ingelheim Pharma, Germany – “Virus Safety Aspects in the Development of a Downstream Process for Recombinant Proteins“

Andrew Sinclair, President & Founder, Biopharm Services, UK - “Continuous Manufacturing, Hybrid Options Transitioning from Batch to Continuous Economics in Downstream Processing“

See Presentations

Download Agenda

" Adding to very good organisations, high-skilled presentations and nice people, this downstream forum is one of my favourite. The forum is open-minded: no restriction regarding suppliers/ brands, all ideas are presented and discussed objectively: working all together to improve our knowledge, share expertise and find new solutions. "

David Delvaille
BPS Project coordinator, MerckSerono Biodevelopment, France

Prof Jose C. Menezes


Prof Jose C. Menezes

About "Quality by Design"

Founder & Managing Director, 4Tune Engineering GmbH, Germany

Dr. Jincai Li


Dr. Jincai Li

About "Speed to Clinic"

Executive Director, Biologics Process Development, Wuxi AppTec Biopharmaceuticals Co., Ltd., China 

Franz Nothelfer


Franz Nothelfer

About "Virus Filtration"

Associate Director Protein Science, Boehringer Ingelheim Pharma, Germany

Andrew Sinclair


Andrew Sinclair

About "Cost Modeling of Bioprocesses"

President & Founder, Biopharm Services, UK 


Ticket Prices

We offer an early bird discount up to April 27, 2018.

The registration fee includes the welcome reception, networking dinner, all breaks and lunches.

Early Bird395 EUR*150 EUR*
Regular550 EUR*170 EUR*

*All prices are excluding VAT



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Any Further Questions?

If you have any further questions, please do not hesitate to contact us.

Nadine Engel +49-551-308-4129

Antje Schneider +49-551-308-1397

Vanessa Henze +49-551-308-2032

Sartorius Stedim Biotech GmbH